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Reports Summarize Bone Marrow Research From N.B. Tavakalyan And Co-A

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  • Reports Summarize Bone Marrow Research From N.B. Tavakalyan And Co-A

    REPORTS SUMMARIZE BONE MARROW RESEARCH FROM N.B. TAVAKALYAN AND CO-AUTHORS

    Hematology Week
    May 31, 2010

    Data detailed in 'Influence of unsaturated carbonic acids on
    hemocompatibility and cytotoxicity of poly-vinylacetate based
    co-polymers' have been presented. According to recent research
    published in the Journal of Materials Science Materials In Medicine,
    "The aim of this study was to investigate hemocompatibility and
    cytotoxicity properties of synthetic polymer coatings containing
    various unsaturated carbonic acids with vinylacetate. Co-polymers of
    vinylacetate and crotonic acid (CA), maleic acid (MA), and itaconic
    acid (IA) were made."

    "The materials were characterized in terms of their adhesion to metal
    supports (titanium and stainless steel) as well as hemocompatibility (%
    hemolysis, wettability, erythrocyte aggregation, hemoglobin content,
    thrombocyte count and lipid peroxidation levels) and cytotoxicity
    (human endothelial cell activity in vitro and chromosome aberrations,
    bone marrow proliferation and cell ploidy in rats).

    Co-polymers of unsaturated carbonic acids with vinylacetate exhibited
    good hemocompatibility properties, as opposed to vinylacetate
    homopolymer for which substantial levels of hemolysis were observed.

    By coating the metal supports with co-polymers the cytotoxic effects
    associated with the bare metal samples were markedly reduced. MA
    samples showed excellent hemocompatibility and no cytotoxicity, yet
    they lacked good adhesion properties to metal substrate, probably
    due to high water content. CA samples, having the highest density
    of carboxylic groups among the samples under investigation, showed
    increased bone marrow proliferation activity and cell ploidy in rats,
    as compared to controls. The most promising results in the present
    study were obtained for the samples with IA, which showed good adhesion
    to metal substrates, good hemocompatibility and low cytotoxicity,"
    wrote N.B. Tavakalyan and colleagues (see also Bone Marrow).

    The researchers concluded: "Thus, co-polymers of vinylacetate and IA
    rich in carboxylic groups are promising materials for the design of
    novel drug-eluting stents."

    Tavakalyan and colleagues published their study in the Journal
    of Materials Science Materials In Medicine (Influence of
    unsaturated carbonic acids on hemocompatibility and cytotoxicity of
    poly-vinylacetate based co-polymers. Journal of Materials Science
    Materials In Medicine, 2010;21(5):1693-702).

    For additional information, contact N.B. Tavakalyan, Yerevan Institute
    Plastpolymer, Arshakunyats Avenue 127, 0007, Yerevan, Armenia.




    From: A. Papazian
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