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STUDIES FROM INSTITUTE OF CHEMICAL PHYSICS REVEAL NEW FINDINGS ON PROTECTIVE AGENTS
Science Letter
June 15, 2010
Data detailed in 'Antioxidant and electron donating function of
hypothalamic polypeptides: galarmin and Gx-NH2' have been presented.
According to a study from Yerevan, Armenia, "Chemical mechanisms
of antioxidant and electron donating function of the hypothalamic
proline-rich polypeptides have been clarified on the molecular level.
The antioxidant-chelating property of Galarmin and Gx-NH(2) was
established by their capability to inhibit copper(II) dichloride
catalyzed H(2)O(2) decomposition, thus preventing formation of HO(*)
and HOO(*) radicals."
"The antiradical activity of Galarmin and Gx-NH(2) was determined
by their ability to react with 2,2-diphenyl-1-picrylhydrazyl
radical applying differential pulse voltammetry and UV-Vis
spectrophotometry methods. Galarmin manifest antiradical activity
towards 2,2-diphenyl-1-picrylhydrazyl radical, depending on the
existence of phenolic OH group in tyrosine residue at the end of the
molecule," wrote L.A. Tavadyan and colleagues, Institute of Chemical
Physics (see also Protective Agents).
The researchers concluded: "The presence of antiradical activity and
reduction properties of Galarmin are confirmed by the existence of an
oxidation specific peak in voltammograms made by differential pulse
voltammetry at E (composite function)=0.795 V vs. Ag/Ag(+) aq."
Tavadyan and colleagues published their study in Neurochemical
Research (Antioxidant and electron donating function of hypothalamic
polypeptides: galarmin and Gx-NH2. Neurochemical Research,
2010;35(6):947-52).
For more information, contact L.A. Tavadyan, Laboratory of Liquid
Phase Free Radical Reactions, ABNalbandyan Institute of Chemical
Physics NAS RA, 5, 2 Sevak str, Yerevan, 0014, Armenia.
Publisher contact information for the journal Neurochemical Research
is: Springer, 233 Spring Street, New York, NY 10013, USA.
From: A. Papazian
Science Letter
June 15, 2010
Data detailed in 'Antioxidant and electron donating function of
hypothalamic polypeptides: galarmin and Gx-NH2' have been presented.
According to a study from Yerevan, Armenia, "Chemical mechanisms
of antioxidant and electron donating function of the hypothalamic
proline-rich polypeptides have been clarified on the molecular level.
The antioxidant-chelating property of Galarmin and Gx-NH(2) was
established by their capability to inhibit copper(II) dichloride
catalyzed H(2)O(2) decomposition, thus preventing formation of HO(*)
and HOO(*) radicals."
"The antiradical activity of Galarmin and Gx-NH(2) was determined
by their ability to react with 2,2-diphenyl-1-picrylhydrazyl
radical applying differential pulse voltammetry and UV-Vis
spectrophotometry methods. Galarmin manifest antiradical activity
towards 2,2-diphenyl-1-picrylhydrazyl radical, depending on the
existence of phenolic OH group in tyrosine residue at the end of the
molecule," wrote L.A. Tavadyan and colleagues, Institute of Chemical
Physics (see also Protective Agents).
The researchers concluded: "The presence of antiradical activity and
reduction properties of Galarmin are confirmed by the existence of an
oxidation specific peak in voltammograms made by differential pulse
voltammetry at E (composite function)=0.795 V vs. Ag/Ag(+) aq."
Tavadyan and colleagues published their study in Neurochemical
Research (Antioxidant and electron donating function of hypothalamic
polypeptides: galarmin and Gx-NH2. Neurochemical Research,
2010;35(6):947-52).
For more information, contact L.A. Tavadyan, Laboratory of Liquid
Phase Free Radical Reactions, ABNalbandyan Institute of Chemical
Physics NAS RA, 5, 2 Sevak str, Yerevan, 0014, Armenia.
Publisher contact information for the journal Neurochemical Research
is: Springer, 233 Spring Street, New York, NY 10013, USA.
From: A. Papazian