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DATA ON ESCHERICHIA COLI THERAPY PUBLISHED BY RESEARCHERS AT YEREVAN STATE UNIVERSITY, DEPARTMENT OF BIOPHYSICS
Drug Law Weekly
February 13, 2007
ESCHERICHIA COLI THERAPY;
Data detailed in "Redox sensing by Escherichia coli: effects of
copper ions as oxidizers on proton-coupled membrane transport" have
been presented. According to recent research from Yerevan, Armenia,
"Escherichia coli is able to grow under anaerobic fermentation
conditions upon a decrease in redox potential (E(h)). Indeed, upon a
transition of E. coli MC4100 wild-type culture to stationary growth
phase a decrease in E(h) from the positive values (approximately
+100 mV) to the negative ones (approximately -520 mV) was observed,
the acidification of the medium and the H(2) production were obtained."
"An oxidizer, copper ions (Cu(2+)) affected a bacterial growth in a
concentration-dependent manner (of 0.1 mM to 10 mM) increasing latent
(lag) growth phase duration, delaying logarithmic (log) growth phase
and decreasing specific growth rate. Acidification of the medium
and the N,N'-dicyclohexylcarbodiimide (DCCD)-and azide-sensitive
proton-potassium exchange by bacteria were inhibited, H(2) production
upon growth and under assays disappeared with Cu(2+) (0.1 mM). These
effects were observed with hycE but not hyfR and hyc(A-H) mutants
and under aerobic conditions. Cu(2+) also increased membrane proton
conductance. Copper ions are suggested to affect directly the
F(0)F(1)-ATPase associated with potassium uptake transport system
and/or formate hydrogenlyase composed with hydrogenase 4," wrote G.
Kirakosyan and colleagues, Yerevan State University, Department
of Biophysics.
The researchers concluded: "A role of the F(0)F(1)-ATPase in redox
sensing under fermentation is proposed."
Kirakosyan and colleagues published their study in Bioelectrochemistry
(Redox sensing by Escherichia coli: effects of copper ions as oxidizers
on proton-coupled membrane transport.
Bioelectrochemistry, 2007;70(1):58-63).
For additional information, contact G. Kirakosyan, Biological Faculty,
Dept. of Biophysics, Yerevan State University, 1 Alex Manoukian Str,
375025 Yerevan, Armenia.
Publisher contact information for the journal Bioelectrochemistry is:
Elsevier Science SA, PO Box 564, 1001 Lausanne, Switzerland.
Keywords: Armenia, Yerevan, Escherichia coli Therapy, Copper, Drugs,
Escherichia coli, Pharmaceuticals, Therapy, Treatment.
This article was prepared by Drug Law Week editors from staff and
other reports. Copyright 2007, Drug Law Week via NewsRx.com.
Drug Law Weekly
February 13, 2007
ESCHERICHIA COLI THERAPY;
Data detailed in "Redox sensing by Escherichia coli: effects of
copper ions as oxidizers on proton-coupled membrane transport" have
been presented. According to recent research from Yerevan, Armenia,
"Escherichia coli is able to grow under anaerobic fermentation
conditions upon a decrease in redox potential (E(h)). Indeed, upon a
transition of E. coli MC4100 wild-type culture to stationary growth
phase a decrease in E(h) from the positive values (approximately
+100 mV) to the negative ones (approximately -520 mV) was observed,
the acidification of the medium and the H(2) production were obtained."
"An oxidizer, copper ions (Cu(2+)) affected a bacterial growth in a
concentration-dependent manner (of 0.1 mM to 10 mM) increasing latent
(lag) growth phase duration, delaying logarithmic (log) growth phase
and decreasing specific growth rate. Acidification of the medium
and the N,N'-dicyclohexylcarbodiimide (DCCD)-and azide-sensitive
proton-potassium exchange by bacteria were inhibited, H(2) production
upon growth and under assays disappeared with Cu(2+) (0.1 mM). These
effects were observed with hycE but not hyfR and hyc(A-H) mutants
and under aerobic conditions. Cu(2+) also increased membrane proton
conductance. Copper ions are suggested to affect directly the
F(0)F(1)-ATPase associated with potassium uptake transport system
and/or formate hydrogenlyase composed with hydrogenase 4," wrote G.
Kirakosyan and colleagues, Yerevan State University, Department
of Biophysics.
The researchers concluded: "A role of the F(0)F(1)-ATPase in redox
sensing under fermentation is proposed."
Kirakosyan and colleagues published their study in Bioelectrochemistry
(Redox sensing by Escherichia coli: effects of copper ions as oxidizers
on proton-coupled membrane transport.
Bioelectrochemistry, 2007;70(1):58-63).
For additional information, contact G. Kirakosyan, Biological Faculty,
Dept. of Biophysics, Yerevan State University, 1 Alex Manoukian Str,
375025 Yerevan, Armenia.
Publisher contact information for the journal Bioelectrochemistry is:
Elsevier Science SA, PO Box 564, 1001 Lausanne, Switzerland.
Keywords: Armenia, Yerevan, Escherichia coli Therapy, Copper, Drugs,
Escherichia coli, Pharmaceuticals, Therapy, Treatment.
This article was prepared by Drug Law Week editors from staff and
other reports. Copyright 2007, Drug Law Week via NewsRx.com.